Acitretin: What It Is, How It Works, and What Alternatives Exist

When your skin won’t respond to creams or light therapy, acitretin, a synthetic retinoid derived from vitamin A, used to treat severe psoriasis and other stubborn skin conditions. Also known as Soriatane, it works by slowing down the overgrowth of skin cells that cause thick, scaly patches. Unlike topical treatments, acitretin acts from the inside—changing how your skin grows at a cellular level. It’s not a quick fix, but for people with plaque psoriasis, pustular psoriasis, or severe recalcitrant acne that won’t budge, it can be life-changing.

Acitretin doesn’t work alone. It’s often paired with UV light therapy (phototherapy) to boost results. But it’s not for everyone. Women who can get pregnant must avoid it completely—because it can cause serious birth defects, even years after stopping. Men and women need to use strict birth control, and blood tests are required before and during treatment. It also interacts with alcohol, making it dangerous to drink while taking it. Side effects like dry lips, peeling skin, and elevated cholesterol are common, but manageable with proper care.

People looking at acitretin often wonder about alternatives. methotrexate, an immunosuppressant used for psoriasis and autoimmune conditions is a common option, especially if you can’t take retinoids. cyclosporine, another immune system modulator works fast but isn’t safe for long-term use. Biologics like adalimumab or ustekinumab are newer, targeted options that help when traditional drugs fail—but they’re expensive and require injections. For milder cases, topical retinoids like tazarotene or calcipotriol might be enough.

The posts below cover real comparisons between acitretin and other treatments—what works, what doesn’t, and who should avoid what. You’ll find direct side-by-side looks at how acitretin stacks up against methotrexate, biologics, and even natural approaches. There’s also guidance on managing side effects, understanding lab results, and knowing when to switch. Whether you’re newly diagnosed or have been on multiple treatments, these guides cut through the noise and give you clear, practical answers—not marketing.